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Nhà Sản phẩmCancer Treatment Steroids

Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
    • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment
  • Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment

    Thông tin chi tiết sản phẩm:

    Place of Origin: China
    Hàng hiệu: Sendi
    Chứng nhận: SGS,ISO9001
    Model Number: 928326-83-4

    Thanh toán:

    Minimum Order Quantity: 10 Grams
    Giá bán: 1.5 usd dollars per gram
    Packaging Details: Discreet and safe foil bag
    Delivery Time: Within 12hours after payment
    Payment Terms: West Union, T/T, Money Gram.,Bitcorn and bank transfer, D/P
    Supply Ability: 10000 Kg
    Liên hệ với bây giờ
    Chi tiết sản phẩm
    Name: Nintedanib CAS: 928326-83-4
    MF: C31H33N5O4 Description: White powder
    Grade Standard: Pharmaceutical grade Other name: BIBF 1120
    Assay: 99% Category: Cancer Treatment Steroids

    Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment


    Product name Nintedanib
    CAS NO. 656247-17-5
    Synonyms Nintedanib
    Category Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals.
    Standard purity:>99%
    Appearance Nintedanib powder
    Shelf life 2 years
    Usage Nintedanib is used to treat some types of non-small-cell lung cancer and for idiopathic pulmonary fibrosis.
    Storage Nintedanib should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.


    Grade Standard: Pharmaceutical grade Purity: 98%
    Place of Origin:China


    1. Nintedanib is a medication used for the treatment of idiopathic pulmonary fibrosis (IPF) and along with other medications for some types of non-small-cell lung cancer.

    2. Common side effects include abdominal pain, vomiting, and diarrhea.It is a small molecule tyrosine-kinase inhibitor, targetingvascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor receptor (PDGFR).

    3. It's dveloped by Boehringer Ingelheim. At an assumed cost of 39,300 pounds per year it does not appear to be cost effective for IPF in the United Kingdom.



    1. Nintedanib BIBF (1120) is a kind of effective triple vessel kinase inhibitor, on VEGFR1 / two-thirds, FGFR1/2/3 and PDGFR alpha/beta has inhibitory effect on the IC50 of 34 nM / 13 nM / 13 nM respectively, 37 nM / 69 nM / 69 nM and 59 nM / 65 nM. Phase 2.BIBF1120 inhibits PDGFR kinase activity of PDGFR alpha and PDGFR beta types with IC50 values of 59 nM and 65 nM, respectively.


    2. In addition, BIBF1120 suppresses the FGFR subtypes with IC50 of 60 nM, 37 nM and 108 nM for FGFR1, FGFR2, and FGFR3, respectively. BIBF1120 binds to the ATP-binding site in the cleft between the amino and carboxy terminal lobes of the kinase domain.


    3. The indolinone scaffold forms two hydrogen bonds with the backbone nitrogen of Cys919 and the backbone carbonyl oxygen of Glu917 in the hinge region.


    4. IBF 1120 inhibits proliferation of PDGF-BB stimulated BRPs with EC50 of 79 nM in cell assays. BIBF1120 at concentrations as low as 100 nM blocks activation of MAPK after stimulation with 5% serum plus PDGF-BB.


    5. In cultures of human vascular smooth muscle cells (HUASMC), BIBF1120 prevents PDGF-BB stimulated proliferation with an EC50 of 69 nM.

    a. In food additives field
    b. In cosmetics field
    c. In pharmaceutical field

    Nintedanib COA:


    Item Index
    Supreme grade First grade
    Color, pt-Co scale ≤ 10 20
    Purity, %(m/m) ≥ 99.9 99.7
    Benzene content, mg/kg ≤ 50 100
    n-Hexane content, mg/kg ≤ 200 500
    Methyl cyclohexane content, mg/kg ≤ 200 500
    Methyl cyclopentane content, mg/kg ≤ 150 400
    Distillation range at 101.3kPa,
    Including 80.7° C, ° C ≤
    1 1.5
    Sulphur content, mg/kg ≤ 1 2
    Nonvolatile content, mg/ 100ml ≤ 1 5
    Density, 20° C, km/m3 0.777-0.782

    Package details:
    1kg/Aluminum foil bag
    1kg/ Aluminium Tin
    25kg/ Aluminum Drum
    Delivery Time:
    Usually within 2 working days after confirming the payment.
    Shipping details:
    DHL; TNT; UPS or EMS

    Hot sales products:


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    Our commitment:

    1. Any inquiries will be replied within 12 hours.
    2. Dedication to quality, supply & service.
    3. Strictly on selecting raw materials.
    4. OEM/ODM Available.
    5. Reasonable & competitive price, fast lead time.
    6. Sample is available for your evaluation & Formulation development.
    7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
    8. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
    9. After-Sale Service:
    (1) International Authorized Third-Party Test For The Products You Demand.
    (2) 60 Days Warranty of quality of goods.

    Nintedanib 928326-83-4 (BIBF 1120) Fibrosis Pharmaceutical Powder of The Lungs Treatment


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    Chi tiết liên lạc
    Shenzhen Sendi Biotechnology Co.Ltd.

    Người liên hệ: Demi

    Tel: +8618123940985

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