|Place of Origin:||China|
|Minimum Order Quantity:||10 Grams|
|Giá bán:||1.5 usd dollars per gram|
|Packaging Details:||Discreet and safe foil bag|
|Delivery Time:||Within 12hours after payment|
|Payment Terms:||West Union, T/T, Money Gram.,Bitcorn and bank transfer, D/P|
|Supply Ability:||10000 Kg|
|MF:||C28H24FN3O5||Description:||White to off-white powder|
|Functions:||Anticancer small molecule inhibitors||Assay:||99.00%|
Anticancer small molecule inhibitors Cabozantinib (XL184) CAS 849217-68-1
N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;Cabozantinib;N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide;XL184;Cabozantinib(XL184);XL-184 free base (Cabozantinib);BMS907351;N-(4-((6,7-DiMethoxyquino.
|CAS Registry Number||849217-68-1|
|Appearance||White to off-white powder|
|Loss on drying||Not more than0.5%|
|Chemical name||Cabozantinib; XL184; N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide|
What cabozantinib is ?
Cabozantinib is a treatment for a rare type of thyroid cancer called medullary thyroid cancer. It is for people who can’t have surgery or whose cancer has spread to another part of the body.
You may have cabozantinib as part of clinical trials for other types of cancer.
Cabozantinib is also called by its brand name Cometriq.
Cabozantinib (marketed under the tradename Cometriq, formerly known as XL184) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM. XL-184 also displays potent activity against Met, Ret, Kit, FLT1, FLT3, FLT4, Tie2, and AXL. XL184 at low concentration(0.1-0.5 μM) is sufficient to induce marked inhibition of constitutive and inducible Met phosphorylation and its resultant downstream signaling in MPNST cells, and inhibit HGF-induced MPNST cell migration and invasion.
How cabozantinib works
Cabozantinib is a cancer growth blocker. It works by blocking particular proteins called protein kinases on cancer cells. The protein kinases encourage the cancer to grow. Cabozantinib blocks a number of these proteins and is called a multi kinase inhibitor. It also stops the cancer cells growing blood vessels, which the cells need to be able to grow.
Cabozantinib may shrink the cancer or stop it growing for a time.
|Appearance||White to whitish crystal powder||Conforms|
|Loss on drying||NMT 0.5%||0.33%|
|Residue on ignition||NMT 0.1%||Conforms|
|Heavy metal||NMT 20ppm||Conforms|
|Assay (HPLC)||NLT 99.5%||99.77%|
|Related substances||NMT 0.5%||0.23%|
|Single impurity||NMT 0.1%||0.07%|
|Conclusion: Complies to the Enterprise standard|
How you have cabozantinib ?
Cabozantinib comes as capsules. You take them once a day. Swallow them whole and don’t open them. The capsules come in different colours – orange and grey. How many you take depends on your needs. Your doctor may change the dose during the treatment.
You should take the capsules at the same time each day. Don’t eat for at least 2 hours before you take them and for an hour after taking them.
If you forgot to take a dose and it is more than 12 hours until your next dose then take the missed dose and the next dose as normal.
If you forgot to take a dose and it is less than 12 hours until your next dose then miss that dose and take your next dose as normal.
It is very important that you take the tablets according to the instructions your doctor or pharmacist gives you. For example, whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream. So check the pack leaflet and follow the instructions it gives. You should take the right dose, not more or less. And never stop taking a cancer drug without talking to your specialist first.
You usually carry on taking cabozantinib for as long as it is working, or until the side effects get too bad.
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